COSMIC² is a platform that runs protein structure prediction jobs at the San Diego Supercomputer Center. Unlike Google Colab notebooks, COSMIC2 jobs run on high-performance computing GPU nodes and have a maximum run time of 48 hours.
We currently offer the following tools:
To learn more about the differences between these tools, check out this blog post.
Grouped by job type
- Predict single protein structure
- AlphaFold2
- ColabFold
- OmegaFold
- Predict structure of protein complex (>1 protein sequence)
- AlphaFold Multimer
- ColabFold
- Predict antibody structure
- IgFold
But wait, what’s the difference between AlphaFold Multimer & ColabFold?
AlphaFold Multimer runs the bona fide AlphaFold Multimer code released by DeepMind. ColabFold is a modified AlphaFold Multimer, where the multiple sequence alignment step is replaced by interrogating a mmseq database.
Recommendation: Start with ColabFold first since it is faster and produces similar results to AlphaFold Multimer. If you are not getting high quality predictions from ColabFold, then try AlphaFold Multimer.